Optimizing cell therapies for Solid Tumors.
Predict and select immune cells with superior tumor-infiltrating potential for improved outcomes.
The only platform that predicts tumor infiltration
| Flow Cytometry | Spatial Imaging | Organ-on-Chip | Infiltrate Bio | |
|---|---|---|---|---|
| Predict Infiltration | ❌ | ❌ | ❌ | ✓ |
| Quantitative Function | ❌ | ❌ | ❌ | ✓ |
| Cell Enrichment | ✓ | ❌ | ⚠(Limited) | ✓ |
| Analysis Type | Endpoint | Endpoint | Observational | Predictive |
Meet the Adhesion Chromatography Platform
The only technology designed for predictive tumor infiltration
Predicting tumor infiltration.
Infiltrate Bio has developed a platform that predicts and enriches for immune cells with superior tumor-infiltrating potential. This microfluidic technology models the tumor vasculature to identify cell products most likely to traffic to solid tumors—a critical bottleneck in adoptive cell therapies.
By enabling the functional selection of cells based on their homing capabilities, this platform supports improved efficacy, manufacturing processes, and clinical translation of cell therapies. Our adhesion chromatography approach transforms how immunotherapies are developed and deployed, providing the first predictive tool for cell therapy success in solid tumors.
How It Works
From Functional Screening to Predictive Enrichment
Our platform consists of microfluidic channels with tumor-associated adhesion molecules. Cells flow through under physiological conditions, separating based on their adhesion characteristics:
- Adherent Cell Identification: Cells with stronger adhesion to the functionalized surface demonstrate enhanced tumor infiltrating potential
- Free-Flowing Cell Separation: Non-adherent cells continue flowing through the channel, indicating poor tumor infiltration capacity
- Cell Enrichment: Live, viable adherent cells with enhanced tumor-infiltrating capabilities can be collected for expansion, analysis, or direct application
Why It Matters
Solving the Critical Bottleneck in Cell Therapy Development
Our platform models the mechanism of tumor infiltration. The adhesion behavior observed in our channels is predictive of in vivo performance:
- Tumor Infiltrating Lymphocytes (TILs): Highly adherent cells demonstrate superior tumor trafficking and infiltration in preclinical models, demonstrating functional correlation with in vivo efficacy
- Circulating T Cells: Free-flowing cells mirror those that remain in circulation without extravasating from blood vessels to reach tumor sites
- Development Impact: Predict infiltration success early, optimize manufacturing processes, and accelerate clinical translation with functional readouts that correlate with therapeutic outcomes
Ready to identify which cells will infiltrate tumors and deliver results?
Our proprietary adhesion characterization platform reveals the biomarkers that predict cell therapy performance, accelerating your development timeline.
Request a ConsultationOur scientific collaborators and partners
Built on world-class partnerships
